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FAQ
What are the types of liquid deep fermentation?
Liquid Deep Fermentation
1. Operation Methods of Liquid Deep Fermentation. Depending on the operation method, liquid deep fermentation mainly includes batch fermentation, continuous fermentation, and fed-batch fermentation.
1. Batch Fermentation. Nutrients and strains are added at once for cultivation until the end, with no material exchange with the outside except for air entering and exhaust gas being discharged. Characteristics: one-time; during fermentation, nutrients continuously decrease, microorganisms continuously proliferate, and the environment is non-steady state; the four periods of microbial growth are distinct. Application: Widely used.
2. Continuous Fermentation. Continuous fermentation refers to the process of adding fresh culture medium to the fermentation tank at a constant rate while simultaneously removing culture liquid at the same rate, thus maintaining a constant liquid volume in the fermentation tank, allowing microorganisms to grow in a stable state. The stable state can effectively extend the logarithmic phase in batch cultivation. Characteristics: equal amounts of culture medium flow in and out; various changes = 0; the four periods of microbial population growth do not exist. Application: Commonly used in wastewater treatment, gluconic acid, alcohol, amino acid fermentation, and other industries. Advantages: stable operation; conducive to machinery and automation; improves equipment utilization; reduces sterilization frequency; easy to optimize processes. Disadvantages: prone to contamination; microorganisms are prone to mutation; limited adaptability to product types; high requirements for equipment and accessories.
3. Fed-Batch Fermentation. Fed-batch fermentation, also known as semi-continuous fermentation, is a fermentation technology that lies between batch fermentation and continuous fermentation, referring to the technique of supplementing certain materials to the culture system in microbial batch fermentation. By supplementing materials to the culture system, the concentration of nutrients in the culture liquid can be maintained within a certain range for a longer time, ensuring the growth needs of microorganisms without causing adverse effects, thus achieving the goal of increasing yield. Characteristics: can relieve substrate inhibition, product inhibition, decomposition hindrance, or overcome excessive microbial growth; improve the conversion rate of useful products; Application: Widely used in industries such as bread yeast, amino acids, antibiotics, etc.
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